Mark Little

Mark was appointed as the Fottrell Professor of Nephrology, School of Medicine, Trinity Translational Medicine Institute, in 2012. He is a Fellow of Trinity College Dublin and of the Royal College of Physicians (London), and a Consultant Nephrologist in Tallaght and Beaumont Hospitals.

He is an international leader in Translational Autoimmune Disease with a focus on the rare condition ANCA vasculitis. He is a Principal Investigator in the Trinity Translational Medicine Institute (, the Trinity Biomedical Sciences Institute ( and the ADAPT centre, thus spanning the full range of experimental investigation from cell to patient to digital application. At a European level, he is a coordinator of the rare immune disorders European Reference Network (, coordinator of The Health Data Linkage for Clinical Benefit (HELICAL) MSCA Innovative Training Network and Registry lead for the European Vasculitis Society (

He is addressing the following experimental questions:
– Can environmental factors and/or pathogens be identified that are associated with disease flares for patients with ANCA vasculitis?
– How should such data be best integrated with other fixed patient-level data and external medical influences, to support near real-time analysis?
– Can a suitable statistical model be derived that allows for a better understanding of the risk of flare up for a patient at a given point in time, which can be used to inform subsequent benefit-risk decisions regarding the need for relevant therapies?