Mark Little

Mark was appointed as the Fottrell Professor of Nephrology, School of Medicine, Trinity Translational Medicine Institute, in 2012. He is a Fellow of Trinity College Dublin and of the Royal College of Physicians (London), and a Consultant Nephrologist in Tallaght and Beaumont Hospitals.

He is an international leader in Translational Autoimmune Disease with a focus on the rare condition ANCA vasculitis. He is a Principal Investigator in the Trinity Translational Medicine Institute (https://www.tcd.ie/ttmi/), the Trinity Biomedical Sciences Institute (https://www.tcd.ie/biosciences/) and the ADAPT centre, thus spanning the full range of experimental investigation from cell to patient to digital application. At a European level, he is a coordinator of the rare immune disorders European Reference Network (http://rita.ern-net.eu/about-rita/governance/), coordinator of The Health Data Linkage for Clinical Benefit (HELICAL) MSCA Innovative Training Network and Registry lead for the European Vasculitis Society (http://www.vasculitis.org/default.aspx?code=1107).

He is addressing the following experimental questions:
– Can environmental factors and/or pathogens be identified that are associated with disease flares for patients with ANCA vasculitis?
– How should such data be best integrated with other fixed patient-level data and external medical influences, to support near real-time analysis?
– Can a suitable statistical model be derived that allows for a better understanding of the risk of flare up for a patient at a given point in time, which can be used to inform subsequent benefit-risk decisions regarding the need for relevant therapies?